The
study from the Pitie-Salpetriere Hospital, Pierre and Marie Curie University
concluded that nonalcoholic fatty liver disease (NAFLD) is an independent risk
factor for atherosclerosis and therefore, cardiovascular disease (CVD).
Their findings recommend strict monitoring of cardiovascular health and metabolic
complications in patients with NAFLD.
"Evidence indicates that the fatty and inflamed liver expresses several
pro-inflammatory and procoagulant factors, as well as genes involved in
accelerated atherogenesis," explained lead investigator Raluca Pais.
Senior author Vlad Ratziu added, "This raises the possibility that the
link between NAFLD and cardiovascular mortality might not simply be mediated by
shared, underlying, common risk factors, but rather that NAFLD independently
contributes to increasing this risk."
Investigators undertook a large retrospective study of close to 6,000 patients
referred to the Primary Cardiovascular Prevention Center at Pitie-Salpetriere
Hospital, Paris between 1995 and 2012 to assess whether NAFLD is incidental to
or is the cause of atherosclerosis of the carotid arteries, the major blood
vessels in the neck that supply blood to the brain, neck, and face.
The team concluded that in patients with metabolic syndrome at risk for
cardiovascular events, NAFLD contributes to early atherosclerosis and its
progression, independent of traditional cardiovascular risk factors.
Senior author Vlad Ratziu added, "This raises the possibility that the
link between NAFLD and cardiovascular mortality might not simply be mediated by
shared, underlying, common risk factors, but rather that NAFLD independently
contributes to increasing this risk."
Investigators undertook a large retrospective study of close to 6,000 patients
referred to the Primary Cardiovascular Prevention Center at Pitie-Salpetriere
Hospital, Paris between 1995 and 2012 to assess whether NAFLD is incidental to
or is the cause of atherosclerosis of the carotid arteries, the major blood
vessels in the neck that supply blood to the brain, neck, and face.
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